Sofia was born in Paris. In 2009, Sofia Lesaffre's grandmother put her on the cast of Les Mythos (2011), which allowed her to get a small role in this comedy. Wanting to continue in this direction, the young Parisian is revealed to a wider audience three years later with Les trois frères, le retour (2014). The actress plays an important character, the daughter of Bernard Campan. Sofia then has a secondary role in the comedy Nous trois ou rien (2015) and drama Le ciel attendra (2016), and then kidnaps the daughter of the boss of his parents in La nuit rebelle (2016). 2017 is an important year in her career with the science fiction film Seuls (2017), in which she plays the heroine who suddenly finds herself alone (or almost) in a deserted society. As her roles grew in importance, Sofia Lesaffre was the main protagonist of the award-winning Belgian romantic drama Pour vivre heureux (2018) and appeared in the shocking film Les misérables (2019) during a striking scene with the police officers of the BAC Damien Bonnard and Alexis Manenti. A year later, she plays for Netflix the daughter of Sami Bouajila in the violent La terre et le sang (2020), directed by Julien Leclercq. Between 2021 and 2022 she has acted in the TV series Braqueurs (2021), or in films such as the romantic drama Une histoire d'amour et de désir (2021), in Selon la police (2022) or in the French-Belgian horror story Deep Fear (2022). He continues his collaboration with Belgian cinema in comedy Habib, la grande aventure (2022). At the 2015 César she was shortlisted "Revelation" for the César for best hopeful female for Les trois frères, le retour (2014).