Blair was born in Detroit, Michigan. He attended L'Anse Creuse High School-North in Macomb Township, MI, where he played tennis. After graduating, he made appearances in commercials for Taco Bell, Pizza Hut and the Honda Civic. He made his major screen debut in 2006 in an episode of CSI: NY (2004). He made his feature debut in the direct-to-video horror-thriller Succubus: Hell-Bent (2007), starring Gary Busey, David Keith and Lorenzo Lamas. His next feature film was the 2008 drama-thriller Big Game (2008), starring C. Thomas Howell and Haley Webb. He landed his first recurring television role on the comedy Hot Hot Los Angeles (2008). Other series appearances included Glee (2009), Heroes (2006), Rizzoli & Isles (2010), 2 Broke Girls (2011), Drop Dead Diva (2009) and The Closer (2005). Blair's next recurring television role came within the sitcom The Hard Times of RJ Berger (2010). Other series he appeared in included The New Normal (2012), Young & Hungry (2014) and Life Sentence (2018) during the 2010's. In addition to his television work, Blair also appeared in film features including Murder Squad (2009), Metro (2011), Detention of the Dead (2012), The Steamroom (2010), Public Relations (2010), Whiplash (2014), Keep It Together (2014), Haunting on Fraternity Row (2018) and Married Young (2019). In 2018, he joined the opening season of the dramedy series Life Sentence (2018), starring Brooke Lyons, Elliot Knight and Pretty Little Liars (2010) star Lucy Hale.